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Tapentadol Usage, Side Effects and Benefits
CHEMICAL PROFILE AND PHARMACOKINETIC DATA
IUPAC Name: 3-[(2R,3R)-1-(dimethylamino)-2-methylpentan-3-yl]phenol
Trade Names: Nucynta, Palexia, Yantil, Tapenta, Tapal, Aspadol etc.
Molecular Formula: C 14 H 23 NO
Molecular Weight: 257.80
Routes of Administration: Oral
Chemical and Physical Properties
Color: White is to off-white color to yellow
State: Crystalline powder
Solubility: Easily dissolves in water, in molten in methyl alcohol, very slightly
soluble in ethanol, almost insoluble in acetone.
Immediate release tablets
Extended release tablets
Tapentadol Side Effects
|Common side effects:||Rare side effects:|
Constipation, Nausea, Stomach Pain, Headache, Drowsiness, Heartburn, Drymouth, Tiredness, Difficulty Falling Asleep Or Staying Asleep
Shallow Breathing, Lightheadedness, Severe Dizziness, Confusion, Problems With Speech, A Seizure, erotonin Syndrome – Agitation, Hallucinations, Faster Heart Rate, Fever Low Cortisol Levels – Loss Of Appetie, Vomiting, Nausea
Tapentadol online (Nucynta) is mainly metabolized in the liver by glucuronidation*process. This medication has low potential for pharmacokinetic drug interferences. When it was given along with naproxen, paracetamol, or aspirin, no change in plasma concentration of Tapentadol was recorded. It does not interact with drugs such as metoclopramide, omeprazole and probenecid. When administered along with other opioid pain relievers, phenothiazines, general anesthetics, hypnotics, sedatives, or other CNS depressants may show adverse effects such as respiratory depression, prolonged sedation, or hypotension.
*Glucuronidation is commonly involved in metabolism of drugs, androgens, bilirubin, glucocorticoids, mineralocorticoids, estrogens, retinoids, fatty acid derivatives, and bile acids. These often involve glycosidic bonds.
Impaired Pulmonary Function
Similar to medicines with μ-opioid agonist activity, Tapentadol pain drug is contraindicated in people with respiratory depression. It is also not recommended in patients with severe bronchial asthma.
Renal and Hepatic Impairment
There is no sufficient clinical data available to establish safety of Tapentadol uses in patients with renal and hepatic dysfunction thus it is not recommended. Consult with your doctor to know more.
Pregnancy and Breastfeeding
Tapentadol has not been studied extensively for usage in pregnancy and thus need to be administered only when needed and under strict medical supervision.This medicine passes into the breast milk and thus not recommended to use in breastfeeding women.
The standard dosage of 100mg is given to elderly with no renal or hepatic impairment. However, if they are dealing with kidney and/or liver disorders administrating low dosages is recommended.
Tapentadol is contraindicated in people who are suspected having paralytic ileus.
Driving and operating machinery
This medication may affect the mental or physical ability of a person requiredto perform tasks that demands undivided attention such as driving vehicle or operating heavy machinery.
Tapentadol shows addictive effects when consumed along with alcohol given its high affinity to attach to μ-opioid receptor. This further leads to the onset of severe drowsiness or dizziness and in rare cases, prolonged sedation, hypotension, coma or death may happen.
Tapentadol has weak effect on the re-uptake of serotonin. Nonetheless, using Tapentadol 100mg with serotonergic medicines such as SNRIs, SSRIs, MAOIs, TCAs, triptans and St John’s wort may cause serotonin syndrome.
The risk of developing withdrawal symptoms increases especially when use of Tapentadol is ceased abruptly. The symptoms may include: insomnia, nausea, pain, anxiety, upper respiratory symptom, sweating etc. In rare cases, hallucinations have been reported. The risk of the onset of online Tapentadol withdrawal symptoms can be reduced by gradually decreasing the dose before completely discontinuing it.
Tapentadol is a schedule II drug which means it has high abuse potential yet it has safe and accepted medical usages. These medicines are abused by drug abusers and people with history of addiction disorders and/or drug/alcohol addiction. Nucynta can be abused in a similar fashion as that of opioid agonists. This needs to be taken into consideration when a doctor or pharmacist is worried about higher chances of drug misuse and abuse.
These concerns should not be obstacle in managing pain. In fact, all patients receiving Tapentadol pain drug need to be monitored for signs and symptoms of abuse and addiction. Usage of μ-opioid agonists often produces high risk of addiction in spite of moderate usage under stringent medical surveillance. The pain drug can be abused by chewing, snorting or injecting. These misconducts often pose a considerable risk that could cause overdose and in rare cases, life-threatening issues.
How long should you take Tapentadol 100mg for?
You need to stick to the dosage regimen designed by your doctor for getting desired and lasting results with Tapentadol 100mg tablets. Generally, the drug is taken every 4 to 6 hours with or without food. In some cases, doctors recommend taking the second dosage as soon as one hour post the first dosage administration.
What are the withdrawal symptoms of Tapentadol Tablets?
When you abruptly stop taking Tapentadol 100mg tablets, you often experience its withdrawal symptoms. Common withdrawal symptoms include nausea, upper respiratory infection, insomnia, nausea, sweating, diarrhea, hallucinations, and tremors. Before you Tapentadol online, you must discuss about the withdrawal symptoms of the pain management drug.
Is Tapentadol better than Tramadol?
Tapentadol causes lesser sleepiness and nausea as compared to Tramadol. The former, being a mu agonist, is better in managing pain than the latter due to its norepinephrine reuptake inhibition properties. Also, Tapentadol 100mg tablets have lesser tendency to cause postoperative nausea and vomiting or PONV than Tramadol.
Does Tapentadol work for nerve pain?
Randomized controlled trials have concluded that Tapentadol showed effectiveness in reducing nerve pain caused by diabetic peripheral neuropathy and chronic lower back pain.
Can you drink alcohol on Tapentadol?
Consuming alcohol while taking the pain management medicines increases your risk of developing side effects such as sleepiness and dizziness.
Can I take Tapentadol with painkillers like paracetamol?
One can get Tapentadol tablets online to consume it along with paracetamol which is a non-prescription painkiller. However, it is vital to inform your doctor about the same.
Can I order Tapentadol online without a prescription?
Tapentadol is a schedule II drug which means it has high potential for abuse and thus its dosage regimen needs to be monitored by a doctor. To ensure reduced risk of withdrawal symptoms, your doctor recommends reducing the dosage strength of Tapentadol for Sale gradually.
Is it legal to buy Tapentadol online?
Yes, it is legal to buy Tapentadol online. Although, given its Schedule II status, the drug has potential for abuse. Therefore, one has to produce a valid prescription before they purchase Tapentadol online.
Is Tapentadol safe long term?
Before you get Tapentadol tablets online, you must know that the medicine has high abuse potential and thus needs to be consumed with great caution. Chances are, Tapentadol 100mg tablets, when consumed in long term may cause mental or physical dependence in the user. It is important to discuss it with a doctor before proceeding with the pain management.